Monday, April 18, 2011

Phytochemicals: modern views and breakthrough in traditional herbal management of sexual dysfunctions

A. Adimoelja
Airlangga University, Surabaya, Indonesia
in 3rd AOAC Meeting, Chiba, Japan (2000)
SUMMARY


Traditional herbs have been a revolutionary breakthrough in the management of erectile dysfunction and have become known world-wide as an 'instant' treatment. The modern view of the management of erectile dysfunction subscribes to a single etiology, i.e. the mechanism of erection. A large number of pharmacological agents are orally consumed and vasoactive agents inserted intraurethrally or injected intrapenially to regain good erection. Modern phytochemicals have been developed from traditional herbs. Phytochemicals focus their mechanism of healing action of the root cause, i.e. the inability to control the proper function of the whole body system. Hence phytochemicals manage erectile dysfunction in the frame of sexual dysfunction as a whole entity. Protodioscin is a phytochemical agent derived from Tribulus terrestris L plant, which has been clinically proven to improve sexual desire and enhance erection via the conversion of protodioscin to DHEA (Dehydroepiandrosterone). Preliminary observations suggest that Tribulus terrestris L grown on different soils does not consistently produce the active component protodioscin. Further photochemical studies of many other herbal plants are needed to explain the inconsistent result found with other herbal plants, such as in diversities of Ginseng, Eurycoma longifolia, Pimpinella pruacen, Muara puama, Ginkgo biloba, Yohimbe etc.


INTRODUCTION


A revolutionary breakthrough in the management of erectile dysfunction (ED) in form of Viagra®, has achieved world-wide recognition as an "instant" treatment for men to regain erection. This medication is reflective to the modern chemical view of ED management which subscribes to a single etiology, i.e. only the mismanaged mechanism of erection. In addition to orally consumed chemical agents, other treatments that conform into this view include intra-urethral vasoactive agents, which are intrapenially injected.


Modern phytochemicals developed form traditional herbs focus their healing mechanism on the root of the dysfunction. The root of ED often also cause imbalance or deficiency in the regulation of the proper functions of other bodily systems, in addition to simply causing the failure to achieve or maintain penile erection in men (2,4). Hence, pythochemical management of ED takes into account the whole body into the frame of sexual dysfunction treatment.


Protodioscin is a phytochemical agent derived from the herbal plant Tribulus terrestris L. It has been clinically tested extensively, and is found to improve sexual drive and to enhance erection in men. The mechanism of protodioscin's action is suspected to involve its conversion to dehydroepiandrosterone (DHEA) as well as testosterone (1,3). This preparation is sold without prescription under the name of Libilov™.


Central to our concern are the efficacy and safety of the use of medicinal plants or plant extracts, which are growing in popularity. Before, this "back to nature" movement relies solely on folklore report on the use of herbal plants in traditional healing practices. The recent advances in phytopharmaceutical purification techniques allow the extraction, purification and standardization of the active components of these plants, which are known generally as phytochemicals (2,4). In turn, the standardization allows scientific research and clinical trials evaluating the benefits and potential hazards of the use of these preparations, to be conducted.


It is not often acknowledged that more than 25% of all "western" medicines contain active ingredients derived from plant sources. In Asian and European countries, physicians often write herbal-based prescription (5), although this is not common practice in the United States. In the evolution of natural medicine, phytochemicals represent the culmination the effort to achieve scientific reputability of these plant-based active ingredients, by ways of scientific research and clinical trials akin to that of chemical drugs. It is hoped that the use of phytochemicals would avoid many of the risk factors associated with synthetic chemicals. Psychopharmacology, phyto-pharmacognosy and ethno-phyto-pharmacognosy (13) of phytochemical studies should therefore be encouraged to create new and safe medicines that conform to the standard precautions of modern medicine, but with minimal undesired toxic effects.


PHARMACODYNAMICS OF PHYTOCHEMICALS


Herbal plants contain chemical compounds, vitamins, plant hormones, minerals and trace elements, most of which function to result in optimal plant growth, to protect the plant from environmental hazards and to attract symbiotic insects required for fertilization. Some of these compounds react holistically with other agents and elements in humans or animals to treat a specific medical ailment and to create a better metabolic balance which contributes to a better sense of well-being and to promote general health.


The philosophy behind the use of active phytochemical from herbal sources rests on the adoption of the natural pharmacodynamic action in the plant itself. In contrast, purifying the phytochemicals to a single agent would simply imitate the chemical production of a synthetic chemical. A single synthetic chemical agent in medicine often affects only a single etiological factor or a mal-mechanism of cell and organ functions. For example, Virag (1982) first introduced the synthetic chemical papaverine to relax the cavernosal smooth muscle in the penis to induce erection in ED patients. Followed by the discovery of the mechanism of erection (de Tejada, 1992 and Shirai, 1992), this constituted a breakthrough in the management of ED. However, the instantaneous effect afforded by this chemical requires repetitive injections to achieve erections. Thus papaverin as a synthetic vasoactive compound in fact does not cure ED. Relaxing the corporal smooth muscle of the penis addresses only one of the problems in the complicated process of penis erection (9,14). This is analogous for other vasoactive compounds such as phentolamine (Regitin®), prostaglandin E1 (Alprostadil®), and other oral synthetic chemicals such as sildenafil citrate (Viagra®), apomorphine SL (Uprima®), and phenotolamine (Vasomax®). These synthetic compounds may indeed offer the benefit of fast action and "instant" erection in ED patients, but in general the use of these compounds are required each and every time to initiate erection. Erection is only one phase out of the four recognized phases of sexual behaviors in men (10). These synthetic chemicals do not address the whole ailment by neglecting to treat the disorder holistically. In contrast, many phytochemicals' actions are to address the root cause of the imbalance and deficiency that result in abnormal functions of cells and organs in the body.


CLINICAL TRIALS ON MALE FERTILITY AND SEXUAL FUNCTIONS


The efficacy and safety of a phytochemical must be established by rigorous testing in both scientific and clinical settings. Protodioscin, the active ingredient in Libilov, has been subjected to many clinical trials, with good results, thus supporting the premise of the benefits of phytochemicals in treating complex ailments such as infertility and ED. Two of these trials are summarized below:


A double-blind, placebo-controlled, multi-center study on 45 subfertile males diagnosed with idiopathic oligoasthenoteratozoospermia was performed to test the efficacy and safety of protodioscin (Libilov). 36 of these men were treated with 500 mg protodioscin / day for 12 weeks, whereas 9 were given placebo. Treatment with Libilov successfully resulted in pregnancies in 8 (22%) of spouses of the treated group, whereas no pregnancy was found in the control group (A. Adimoelja et al., 1995)


In another study, 30 non-diabetic and 15 diabetic male patients with ED or reduced libido were treated with 250 mg Libilov for 3 months. Improved sexual drive was reported in 20 (67%) of the 30 non-diabetic ED men, and in 8 (53%) of the 15 diabetic ED patients. Improvement in sex drive, increase in successful sexual intercourse and enhancement in erection quality were observed in some patients after only 10 days of taking Libilov (A. Adimoelja and P.G. Adaikan, 1997).


THE MECHANISM OF PROTODIOSCIN'S ACTION


Many research efforts have suggested that in the body, protodioscin acts as a precursor to a key hormone dehydroepiandrosterone (DHEA). DHEA levels in diabetic patients, especially those with ED, are much lower than that found in normal men. Even in normal healthy men, the DHEA level steadily declines after reaching middle age. As DHEA is hypothesized to be required for proper maintenance of cell membrane integrity and functions, its lowered amount may result in some aspects for aging, including lowered sex drive and poor erection.


The restoration of sex drive and enhancement of the quality of erection by protodioscin seem to involve its conversion to DHEA and testosterone. Increased DHEA level, in turn prevents the loss of epididymal cells which results in the improved spermiogenesis and increased fertility.


There is an intriguing possibility that DHEA may prevent premature loss of cell membrane integrity. It may also restore the function of endothelial cells lining of corporal sinuses by rejuvenating membranes of those cells. This may lead to a natural anti-aging therapy, which is of particular interest for the aging population. This possibility warrants a more detailed trial of the connection of protodioscin to DHEA.


ETNOBOTANICAL ASPECTS OF MEDICINAL PLANTS


Preliminary observations suggest that Tribulus terrestris L plants which grow on different soil conditions do not consistently produce the active component protodioscin. This is consistent with other studies that suggest inconsistencies in the specific extracted chemical components of other herbal plants such as Ginseng panax, Eurycoma longifolia, Pimpinella pruacen, Muara puama, and Ginkgo biloba (3). This aspect of medicinal plant use needs to be taken into account, as different preparations of crude extracts of one herbal plant harvested from different locations may yield different results.


One solution to this problem is the application of modern advances in purification and standardization of phytochemicals preparation. Only by employing strict pharmaceutical guidelines and quality control steps, the efficacy, safety and homogeneity of herbal based phytochemicals can be ensured.


CONCLUSION


Although synthetic chemical agents may exert quick or immediate response, the slower acting phytochemicals often times are more beneficial in the treatment of many cases of ED. In general, synthetic agents are designed to act on a "single-agent" theory, such as a specific pathogen or a specific malfunction of a cellular process. In contrast, phytochemical agents address diseases in a more holistic approach: by restoring the balance or eliminating certain deficiencies that lead to improper regulation of body functions and processes. In case of protodioscin, the treatment results in improvement of the DHEA levels, which translates to improved sex drive, quality of erection, virility and fertility.


In case of ED, the synthetic chemical agents of today's western medicine are designed for a specific step in the complex process of erection. Although this results in immediate erection after use, it is by no mean a cure for ED: the patient repetitively needs to take the agents to achieve erection. In contrast, protodioscin in form of Libilov, although slower acting, allows its users to regain the ability to achieve erection without taking anything before sexual intercourse.


REFERENCES


1. A. Adimoelja (1997) Treatment of sexual dysfunction in diabetes mellitus patients using orally administered protodioscin and injection of vasoactive compounds. Seminar of Erectile Dysfunction of Diabetes in Bandung, Indonesia.


2. A. Adimoelja (1997) Clinical application of Asian medicine in erectile dysfunction (ED). Int. J. Impotence Research v9, supp 1.


3. A. Adimoelja and P.G. Adaikan (1997). Protodioscin (Libilov) from herbal plant tribulus terrestris L improves the male sexual functions, probably via DHEA. Int. J. Impotence Research v9, supp 1.


4. A. Adimoelja (1999) The application of phytochemicals as aphrodisiac. Seminar on Botanical Aphrodisiacs, UNTAG University, Jakarta, Indonesia (1999)


5. M. Castleman (1995) Healing Herbs. Bantam Books, NY. pp. 1-5


6. S. Chernicske (1996) The DHEA Breakthrough. Ballantine Book , N.Y.


7. A. Gauthaman, P.G. Adaikan, and R. Prasad. Pro-erectile pharmacological effects of Tribulus terrestris extract on the rabbit corpus cavernosum. In preparation.


8. A. Gauthaman, P.G. Adaikan, R. Prasad, V. Goh, and S. Ng. Changes in hormonal parameters secondary to intravenous administration of Tribulus terrestris extract in primates. In preparation.


9. S. Masafumi (1992) Impotence research: progress so far and problems to overcome. Special focus on the mechanism of penile erection. World Book of Impotence, TF Lue eds. Smith Gordon Co publs. Ltd. - Nishimura Co. Ltd.


10. W. Masters and V. Johnson (1981) Sex and the aging process. J Am Geriatr Soc. 1981 Sep;29(9):385-90.


11. N. Moeloek, A. Adimoelja, T. Tanojo, and W. Pangkahila (1994) Trials of Tribulus terrestris (Libilov) on oligozoospermia. Proceedings of the VIth National Congress and IIIrd International Symposium on New Perspectives of Andrology on Human Reproduction National Congress of Indonesian Association of Andrology. Scientific Meeting VI in Manado.


12. R. Sahelian (1996) DHEA, a Practical Guide. Avery Publications, NY.


13. I. Sidik (1999) Etnopharmacognosy and phytochemical aphrodisiac in Seminar on Botanical Aphrodisiacs, UNTAG University, Jakarta, Indonesia (1999)


14. I.S. de Tejada (1992) Mechanism for the regulation of penile smooth muscle contractility. World Book of Impotence, TF Lue eds. Smith Gordon Co publs. Ltd. - Nishimura Co. Ltd.


source: http://www.libilov.com/en/clinical_studies/review_Adimoelja_2000.htm

Tribulus Terrestris Facts, Information, and Research - The Miracle Herb?

Okay, I'd be kidding you if I told you that Tribulus Terrestris is a miracle herb. ;-) But Tribulus Terrestris isn't far off from being a 'super' herb. Let's see why. First, Tribulus Terrestris is a herb used for its medicinal effects around the world. Tribulus is extracted from the plant, and used as a natural nutritional supplement. It has been used for centuries by the Chinese to calm the liver, treat headaches, dizziness, and premature ejaculation.


So what the heck does Tribulus Terresteris have to do with bodybuilding and fitness? Read on...


Quick Tribulus Terrestris Facts


Here are some quick Tribulus facts:


Tribulus Terresteris is ecologically pure
Tribulus is a natural aid to help impotence, low libido, and male infertility
Clinically proven effect vie in enhancing energy and vitality
Helps build muscle and strength
Tribulus Terrestris is safe to use and it's not a hormone
Tribulus Terrestris - Testosterone Enhancer


In bodybuilding, Tribulus is used for its testosterone boosting properties more than anything else. Studies have shown over 50% increase in testosterone levels when taking Tribulus Terresteris. We all know testosterone helps build muscle and strength, that's why some pro athletes use steroids and other prohormones to enhance performance.


You'll be happy to hear that Tribulus Terrestris is NOT a hormone! It works completely different from Andro and DHEA. Tribulus increases testosterone through increasing luteninizing hormone (LH) in your body. LH tells your body to produce testosterone. Why is this beneficial? Simply because Tribulus is not a hormone supplement, it merely works within the body's natural limits helping you achieve muscle and strength.


Tribulus Research and Studies


Much tribulus research and studies have been conducted, and all have shown positive benefits of supplementing Tribulus Terrestris, and almost no adverse effects. Here are some findings on Tribulus supplementation:


A study done with healthy individuals taking 750mg of tribulus per day showed a 72% LH increase, and a 41% increase in testosterone.
In a study conducted with 20 males and females, 75% of the participants had increased endurance, 80% had increased libido and sexual performance, and 95% of the females reported no PMS symptoms.
A study conducted with 200 males suffering from impotence showed increase in LH and testosterone levels after supplementing Tribulus. The study also found a increase in sperm production.


source: http://www.bodybuilding-supplements-for-you.com/supplement-reviews/tribulus-terrestris.htm

Does Tribulus work?“, “What’s the best tribulus supplement?“, “Are there any side effects of tribulus? Review!

I’ve been asked a few times by readers about a particular ‘testosterone booster’.


They’ll say, “Does Tribulus work?“, “What’s the best tribulus supplement?“, “Are there any side effects of tribulus?“.


In order to find out we need to turn away from the manufacturer’s claims and turn to any available research.


Here’s some of the claims:


Increased Testosterone
More Lean Mass
Less Body Fat
Therefore an improved Body Composition
Wow Wee! Just let me grab my wallet real quick!


There are other claims, but I’m looking at it from the perspective of a Muscle Hacker only.


So what do the studies say about its effects? Let’s take a look at 2 studies I have found that have relevance for us…


Study Title: “The effect of five weeks of Tribulus terrestris supplementation on muscle strength and body composition during preseason training in elite rugby league players.” Rogerson S, Riches CJ, Jennings C, Weatherby RP, Meir RA, Marshall-Gradisnik SM. J Strength Cond Res. 2007 May;21(2):348-53. (link)


They studied the effect of tribulus terrestris on strength and fat free mass over 5 weeks of preseason training in elite rugby league players.


22 Australian elite male rugby league players were match-paired and randomly assigned in a double-blind manner to either a tribulus terrestris or placebo group. All subjects performed structured heavy resistance training as part of the club’s preseason preparations. They were given 450mg of T.T. daily.


The Result?


After 5 weeks of training, strength and fat free mass increased significantly without any between-group differences. So the addition of Tribulus terrestris didn’t do anything above what training alone can do.


The researchers concluded…”It was concluded that T. terrestris did not produce the large gains in strength or lean muscle mass that many manufacturers claim can be experienced within 5-28 days.”


Let’s hammer the point home. Here’s another one…


Study Title: “The effects of Tribulus terrestris on body composition and exercise performance in resistance-trained males.”
Antonio J, Uelmen J, Rodriguez R, Earnest C. Int J Sport Nutr Exerc Metab. 2000 Jun;10(2):208-15. (link)


They wanted to studyTribulus terrestris’ effects on body composition and exercise performance in resistance-trained males. Fifteen subjects were randomly assigned to a placebo or tribulus (3.21 mg per kg body weight daily) group.


After 8 weeks they found that there were no changes in body weight, body fat percentage, total body water, dietary intake, or mood states in either group.


Actually, muscle endurance (measured by the max. no. of repetitions at 100-200% of body weight) increased for the bench and leg press exercises in the PLACEBO group! I thought that was pretty cool.


The researchers concluded, “Supplementation with tribulus does not enhance body composition or exercise performance in resistance-trained males.” It sure doesn’t.


So to answer your questions…


Does tribulus work? Nope.


What’s the best tribulus supplement? There aren’t any.


Are there any side effects? Considering that there aren’t any EFFECTS period, I wouldn’t be overly concerned about SIDE effects.


If you’re interested, these are the bodybuilding supplements I DO recommend. And I reveal what I believe to be the best whey protein supplements here.
Thanks for taking the time to read my stuff. As always, I appreciate it!


Your bud,


Mark.


source: http://www.musclehack.com/tribulus-terrestris-review/

CNP Professional Tribulus Terrestris Review

Miracles For Men Product Rating


Tribulus Terrestris is a natural Bulgarian Tribulus Terrestris extract used as a natural testosterone booster for several years. Unlike other testosterone boosters, this product is not filled with cheap and inert Asian material. Many companies producing nutritional body building supplements use the wrong part of the plant to extract Tribulus Terrestris from it. CNP Professional makes sure that the Tribulus Terrestris represents Gold standard and is made from shoot extract.


During our review of this product by CNP Professional, we found out that other testosterone producing supplements are not so effective. This is because Asian Tribulus Terrestris is not at all good, as it is made from berries of the plant, instead of from the shoots. Bulagrain Tribulus Terrestris is effective as it is extracted from the shoot part of the plant to give you the most active ingredients. Our Miracles for Men team gave it an overall good rating of 8 on 10. This was due to the following product features we found out about it:


Tribulus Terrestris by CNP has been developed by a large German company which specializes in the production of phytochemical products
This special formulation of Tribulus Terrestris is standardized for protodioscine content by almost 300%
Due to its high specs, Tribulus Terrestris by CNP produces the effects as those seen in eastern bloc athletes
CNP’s Tribulus Terrestris is available in jars with 90 capsules, which provide 45 servings or 2 tablets/capsules each
The recommended daily dosage for Bulgarian Tribulus Terrestris is two tablets taken twice a day after a meal
You should follow a pattern of taking the capsules 5 days a week, with 2 days off
Each serving provides around 500mg of Tribulus Terrestris Extract
Bulgarian Tribulus Terrestris extract can be used by vegetarians, vegans and those on a gluten free diet
Some of the most important ingredients include Pro-Male proprietary botanical testosterone blend which includes eurycoma longifolia, isolated furostanol saponin complex, protodioscine, pseudoprotodioscine and tribulosaponins A and B along with dicalcium phosphate and magnesium stearate
The jar comes with 90 capsules, which lasts 30 days
The product is completely free from allergens
This product is suitable for those athletes who want to naturally raise their testosterone levels. This is due to the presence of ingredients in the product which stimulate the release of Leutinizing Hormone by the body, which in turn stimulates the production of natural testosternone levels. With CNP Professional Tribulus Terrestris, you can be assured that the product is harvested from the shoot extract and is of high quality.


You will find the product extremely satisfactory, and will find it to be better than other testosterone boosters available on the shelves. CNP Professionals Tribulus Terrestris is completely natural and contains no hormones to artificially raise the testosterone levels in the body. Place your order online now and get your order delivered to you right away from our website. We make sure your order is delivered safely.


source: http://www.miraclesformen.com/cnp-professional-tribulus-terrestris-review

REVIEW - OPTIMUM NUTRITION TRIBULUS TERRESTRIS REVIEW

After trialling this product for 50 days, I try to determine whether Tribulus Terrestris is the holy grail of testosterone production, or simply a libido booster.


OUR REVIEW
Click here to buy tribulus at a highly discounted price!
INTRODUCTION
Over the past few years, there has been much hype over various Tribulus Terrestris products that claim to assist the anabolic process of building muscle, alongside boosting one's libido. The theory goes that it will boost testosterone levels and thus aid the muscle building process.
After trialling this product for 50 days, I try to determine whether this the holy grail of testosterone production, or simply a libido booster.
EFFECTIVENESS
Okay there's no doubt about it. I definitely noticed an increase in my libido as a result of consuming one capsule morning and night. This was very apparent after supplementing for only several days.
But what about the anabolic effect of consuming Tribulus in conjunction with a resistance training regime? Well, this product contains 100 capsules (each 625mg) to be consumed 2 times per day. Do the maths and you'll work out that it lasted me 50 days - more than enough time to notice any considerable changes. However ultimately I found this product to have a minimal effect on my weight lifting results. Sure I was making good gains - but no better than prior to supplementing with Tribulus.
Whilst there is some research to suggest that tribulus may have some benefit on muscle development, the jury is still out there. Consequently I did trial this product with a fair degree of scepticism.
NUTRITIONAL
Tribulus terrestris is a natural herb and has been used for many years in Chinese medicine. It does have a wealth of health benefits associated with supplementation. This particular product has been standardised to 40% furastanol saponins, as is fairly typical with all tribulus products.
VALUE FOR MONEY
Various Tribulus products can cost an arm and a leg. I managed to source it for around the $35 though, which isn't too bad.
Value was a difficult rating because it was hard to quantify the health and potential anabolic benefits from supplementing with this product. I do concede that my "trial" was not under strict testing protocol.
If you're after something to boost your libido however, this may be a very worthwhile product.


CONCLUSION
All in all, a good product if you're after a boost of your libido. Muscle development is up for debate.
There has been several studies into Tribulus Terrestris that have shown significant boosts in testosterone levels. Some studies have also shown strength improvements, yet this is still inconclusive.
I cannot conclude from my own trial that this product is completely ineffective on it's own. Other people would suggest otherwsie and there have been some rave reviews on this particular product. I do highly suggest that you try it out for yourself. Please visit our supplement store to consider buying tribulus terrestris.
Overall for my tribulus review, I have assigned a rating of 3 stars. I do this cautiously because I am still unconvinced as to whether or not tribulus does have a positive anabolic impact.


source: http://www.aminoz.com.au/tribulus-terrestris-review-a-195.html

Tribulus (puncture vine) is a vine that has been used as a general tonic (energy) and herbal treatment for impotence

but is found primarily in dietary supplements marketed for increasing testosterone levels in bodybuilders and power athletes.




Claims:
- Increased testosterone production
- Increased muscle mass/strength




Theory:
The idea behind tribulus is that it may increase testosterone levels indirectly by raising blood levels of another hormone, luteinizing hormone (LH). LH is a hormone produced by the pituitary gland and plays a role in regulating natural testosterone production and serum levels.


Scientific Support:
The active ingredient in tribulus is unknown, but is though to be a component known as furostanol saponins. There has been very little research conducted on the effectiveness of tribulus in elevating testosterone levels – the main claim made by body building products which contain the herb. In some cultures, the tribulus terrestris plant has been used as a "tonic" to in crease energy levels and treat sexual dysfunction (usually in males). In animals, tribulus may stimulate "mounting" behavior. Some European studies suggest that tribulus extract can increase testosterone levels 30-50% above baseline levels – but still well within the normal range. Unfortunately, however, these same studies also suggest a similar increase in estradiol levels – not exactly what the hardcore muscle builders should be interested in boosting


If tribulus extract does indeed elevate testosterone levels somewhat, but keeps them within normal ranges, it may be an effective supplement for individuals with reduced testosterone levels such as athletes at risk for overtraining syndrome and in those individuals on a prolonged low-calorie diet. It will not, however, cause you to start sprouting muscles from all parts of your body, as many body building mags would have you believe.


In one of the few well-controlled studies to examine the effects of tribulus terrestris on body composition and exercise performance looked at 15 resistance-trained males. Subjects received either a placebo or a large dose of tribulus (1.5mg per pound of body weight per day for 2 months). Results showed no changes in body weight, percentage fat, total muscle mass or muscle strength related to tribulus supplementation.


Safety:
Although no significant side effects should be expected at doses of tribulus contained in commercial dietary supplements, animal studies have suggested the possibility of locomotor (muscle coordination) disturbances following ingestion of tribulus in high quantities. In sheep consuming tribulus plant for several months, neurological disease was characterized by an irreversible, asymmetrical, weakness of the hindlimbs.


Value:
Products containing tribulus are typically marketed to bodybuilders and athletes concerned with increasing muscle mass and strength. Although such products are typically combinations of ingredients which include tribulus, rather than tribulus alone, the scientific evidence for product effectiveness is typically lacking. At this time, Supplement Watch does not view tribulus extract (on its own) as a valuable dietary supplement for muscle building. As a support ingredient contained in a wider supplement blend, tribulus may provide some benefits to those individuals interested in maintaining testosterone levels in the normal range (overtrained athletes and dieters).


Dosage:
A typical dosage of 250-1500 mg of tribulus per day is fairly common. Be sure to choose an extract standardized for at least 30-45% steroidal saponins (furostanol).




IronMagazine highly recommends IronMagLab's Tribulus Terrestris, it is the highest quality Tribulus with over 20% Protodioscin the effective part of the herb that raises LH levels, thus increasing natural testosteone production!




References:
1. Antonio J, Uelmen J, Rodriguez R, Earnest C. The effects of Tribulus terrestris on body composition and exercise performance in resistance-trained males. Int J Sport Nutr Exerc Metab. 2000 Jun;10(2):208-15.
2. Arcasoy HB, Erenmemisoglu A, Tekol Y, Kurucu S, Kartal M. Effect of Tribulus terrestris L. saponin mixture on some smooth muscle preparations: a preliminary study. Boll Chim Farm. 1998 Dec;137(11):473-5.
3. Bourke CA. Hepatopathy in sheep associated with Tribulus terrestris. Aust Vet J. 1983 Jun;60(6):189.
4. Bourke CA. Staggers in sheep associated with the ingestion of Tribulus terrestris. Aust Vet J. 1984 Nov;61(11):360-3.
5. Duhan A, Chauhan BM, Punia D. Nutritional value of some non-conventional plant foods of India. Plant Foods Hum Nutr. 1992 Jul;42(3):193-200.
6. Wu G, Jiang S, Jiang F, Zhu D, Wu H, Jiang S. Steroidal glycosides from Tribulus terrestris. Phytochemistry. 1996 Aug;42(6):1677-81.
7. Xu YX, Chen HS, Liang HQ, Gu ZB, Liu WY, Leung WN, Li TJ. Three new saponins from Tribulus terrestris. Planta Med. 2000 Aug;66(6):545-50.
8. Yan W, Ohtani K, Kasai R, Yamasaki K. Steroidal saponins from fruits of Tribulus terrestris. Phytochemistry. 1996 Jul;42(5):1417-22.


source: http://www.ironmagazine.com/review16.html

Tribulus Terrestris Review by raise your testosterone.com

This tribulus terrestris review may stand in contrast to some of the other highly enthusiastic reviews of this supplement on the internet. They did have me excited to try it out, though. This supplement in particular seems to cross over between the athletic/body building communities and the sex-enhancement crowd. Somehow, the flowering plant has gotten all around the world, from eastern Europe, to India, Africa and southeast Asia. Tribulus terrestris is known as puncture vine, caltrop, goathead, Bai Ji Li in traditional Chinese medicine and gokshura in Ayurveda.


Tribulus Terrestris Review: Does it work at all?
Tribulus has some serious exposure in the athletic literature. The human studies are reminiscent of the studies on phosphatidylserine : they show some mild, trending-toward-improvements in the testosterone biometrics, yet they probably have more subtle, yet discernible effect that has athletes coming back for more (1). In my mind the difference between tribulus and phosphatidylserine, however, is that one is already in your body, while tribulus is certainly not. Similar mixed-kinda-sorta positive results were observed in trials of tribulus in combination with other herbs (2,3).


Mixed results notwithstanding, animal and anecdotal evidence and positive tribulus terrestris review write-ups abound. Rats, mice, and primates show some greatly improved sexual zeal when supplemented on the stuff (4,5). And reports all over the internet suggest that sustained use can strongly improve sexual performance.


Tribulus terrestris review: How does it work?
So tribulus barely moves the dial on testosterone levels in humans in real clinical studies. But it still has an effect. What's happening? The active compound in tribulus is protodioscin, which is very similar in structure to DHEA. While DHEA ultimately exerts it's effects in the system by producing more testosterone, it can also be used to produce more estrogen. This proximity may have something to do with the (rare) case reports of gynocomastia ("man boobs") associated with use of tribulus.


Like ginseng and maca, I strongly suspect that the steroid-like compounds in the tribulus are acting directly on hormone receptors in the body. This phenomenon is similar to phytoestrogens-- estrogen-like compounds from nature-- acting on the estrogen receptor in the body to cause physiological effects.


Tribulus terrestris review: The experiment
Like all supplements in this review series, I ordered tribulus terrestris from amazon.com and took two pills per day wednesday through saturday. Like all other supplements in this series, I noticed nothing special in terms of my body physiology. As far as my experience is concerned, I saw no harmful effects in the short term. Note: I wouldn't take anything EXCEPT ginseng over the long term (ginseng has well-established long term medical data, others just have unexamined "history of use").


In this short-term experiment, I observed nothing special in my sexual experience with tribulus terrestris. No extra-strong erections. No super staying power. No wild body sensations. No noticably enhanced desire. Just normal, good sex.


Like other compounds in this report, I would be surprised if this didn't show results with sustained intake. I'm just not up for that kind of experiment on my body right now.


source: http://www.raise-your-testosterone.com/tribulus-terrestris-review.html